Background: Ulcerative colitis (UC) is an acute and inflammatory disease of the large bowel of unknown aetiology. The use of probiotics for this disease remains controversial. The objective of this systematic review was to identify studies based on randomised controlled trials comparing the effect of probiotics to the effect of anti-inflammatory drugs or placebo in the remission of UC.
Methods: We conducted a systematic review of clinical
trials comparing the effect of probiotics to the effect of
anti-inflammatory treatment or placebo in the remission
of UC. PubMed, sciencedirect, Cochrane, Google scholar,
metaregister of Controlled Trials and National institutes
of Health were searched.
results: Nine studies met the inclusion criteria. These
studies present a significant heterogeneity concerning their methodology and their results. The improvement in UC remission and the frequency of adverse effects do not differ significantly between probiotic and control groups.
Conclusions: There are a limited number of randomised
trials published in the field of probiotics used for the
remission of UC, and they present many methodological
differences. The existing studies suggest a similar
safety and efficacy of probiotics in comparison with