Issue: 2004 > Supplement March > articles

NRAMP1 (SLC11A1) and vitamin D receptor genes: disease associations

K.P.W.J. McAdam


Resistance to infectious diseases is complex, being regulated by multiple genes, and so far no one locus has been shown to dominate the susceptibility in outbred human populations. Multi-case families have contributed greatly to defining important host immune response pathways using a candidate gene approach. It is likely that genome scans will identify novel genes for resistance to disease that could help define new approaches to drug and vaccine development.