Issue: 2017 > December > case report

Successful treatment of leptomeningeally metastasised pituitary carcinoma with temozolomide

A. van der Vlist, T.J. Snijders, A.M.E. Stades, W.G.M. Spliet, F.Y.F.L. De Vos
AbstractFull textPDF


A 69-year-old man presented with leptomeningeally metastasised pituitary carcinoma, rapidly progressing despite previous treatment with resection, radiotherapy and cabergoline. The patient received temozolomide chemotherapy, resulting in a complete clinical, radiological and biochemical response after 14 cycles, which has been maintained since then. This case lends further support to the role of temozolomide in refractory pituitary tumours.